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Primary analysisMain studies – The efficacy of sildenafil 25, 50 and 100 mg was compared to placebo in the two fixed dose studies (studies 102, 364), while in the two placebo flexible dose studies, subjects started on a dose of 50 mg (study 103) or 25 mg (study 363) and were allowed to adjust the dose up or down based on efficacy and toleration. viagra generic However, the submitted data did not show consistent or dose-related systemic haemodynamic effects of sildenafil at plasma concentrations up to 25-fold higher than those active on the corpus cavernosum..
In general, sildenafil caused short-lasting falls in blood pressure and left systolic pressure at high doses accompanied by (reflex) increases in heart rate. buy cialis canada patients.
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